Ferroptosis in Neurons: A Bibliometric Analysis of Research Trends, Key Contributions, and Emerging Directions
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Background Neurons are the fundamental structural and functional units of the nervous system, serving as the core cells for information transmission and regulation. They are closely associated with various neurological diseases. Recent studies have shown significant advancements in research on ferroptosis in neurons; however, there has been a lack of bibliometric analysis in this field. This study aims to provide a comprehensive overview of the knowledge structure related to ferroptosis in neurons through bibliometric methods, identify current research trends and hotspots, and predict potential future research directions. Methods We conducted a search for publications related to ferroptosis in neurons from 2014 to 2024 in the Web of Science Core Collection (WoSCC) database. Bibliometric methods were employed to analyze authors, institutions, countries, journals, and references using VOSviewer, CiteSpace, and the R package "bibliometrix". Results This study included 685 articles from 50 countries, with China and the United States being the leading contributors. The number of publications related to ferroptosis in neurons has shown a year-on-year increase. The primary research institutions are Central South University, Harbin Medical University, and the University of Melbourne. Free Radical Biology and Medicine is the most popular journal in the field, while Cell has the highest citation count. A total of 4,673 authors contributed to the research, with David Devos and Ashley I. Bush having the highest number of publications, while Scott J. Dixon had the most co-citations. Keyword analysis revealed that the fundamental molecular mechanisms of ferroptosis and its application in neurological diseases are the primary research focuses in this field. Conclusion This study is the first comprehensive bibliometric analysis summarizing the trends and developments in ferroptosis research in neurons. The study outlines and predicts global research hotspots and trends, providing valuable references for scholars studying ferroptosis.
