CircCAMSAP1 Suppresses Uveal Melanoma Progression via miR-1182 Sponging and NONO Regulation

Uveal melanoma (UM) is an extremely aggressive tumor with an unfavorable prognosis and few therapeutic options. Understanding the critical molecular regulators in UM is essential to improving treatment. Circular RNAs (circRNAs) have recently been recognized as pivotal regulators in cancer, although their roles in UM remain largely unexplored. Here, it was found that circCAMSAP1 was significantly downregulated in UM tissues and cell lines. CircCAMSAP1 was observed to act as a sponge for miR-1182, modulating NONO expression to reduce cell proliferation and induce apoptosis. Clinical analysis showed that patients with high NONO levels had significantly better prognoses. Additionally, bioinformatics analysis of circCAMSAP1-overexpressing cells revealed its association with MAPK signaling pathway. The findings suggest the potential of circCAMSAP1 as a biomarker and target for diagnosing and treating UM, offering new avenues for improving patient outcomes.