Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Obese Patients Receiving Laparoscopic Sleeve Gastrectomy: a study protocol for a prospective randomized controlled trial

Background : Anesthesia for obese patient and postoperative pain management remains a big challenge. Their greater demand for opioids comes with both acute and long-term adverse effects，is calling for opioid-free anaesthetic strategies. Opioid-free anesthesia(OFA) is a multimodal anesthesia associating hypnotics, N-methyl-D-aspartate antagonists, local anesthetics, anti-inflammatory drugs and α-2 agonists to realize enhanced recovery after surgery(ERAS). With further research, we have confirmed that OFA is safe and feasible for laparoscopic surgery. However，how to select and combine the application of alternative drugs, need to be carefully selected. Therefore, the formulation of OFA programs and strategies plays a crucial role in ensuring effective suppression of surgical stress and reducing potential adverse reactions and complications of multi-drug combination. Methods : This prospective double-blind, randomized ,controlled clinical trial will incorporate 76 patients scheduled for laparoscopic sleeve gastrectomy(LGS) surgery. The eligible population will be 1:1 randomly assigned to OFA or conventional anesthesia group. Primary endpoint was the 15-item recovery quality scale score after surgery. Discussion : This trial explores the efficacy of opioid-free anesthesia in obesity patients, it provides more superior scheme than conventional one,which using opioid drugs . If OFA achieves positive results in this experiment, it will bring support for the promotion of OFA.It’s not only accelerate postoperative recovery ,but also improve patient satisfaction. Trial Registration : This trial registered at clinical trials.gov (NCT06305221) on 12 March 2024 (https://register.clinicaltrials.gov/prs/app/action/SelectProtocol).