Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Response Index as Biomarkers for the Clinical Outcomes of Intracerebral Hemorrhagic Stroke Patients: A Longitudinal Design Study

This study examines the associations between the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) and clinical outcomes of intracerebral hemorrhagic (ICH) stroke patients. We recruited and investigated longitudinally 294 ICH stroke patients in a general tertiary hospital in Sichuan Province, China at baseline (admission), 1-month post-discharge, 3-month post-discharge and 6-month post-discharge from January 2020 to January 2022. We calculated the NLR and SIRI from blood samples collected at baseline. The Mann-Whitney test, logistic regression analysis and receiver operating characteristic (ROC) analysis were performed to evaluate differences in the NLR and SIRI between hemorrhagic stroke patients at three follow-up time points. The interaction between these variables was evaluated via multiplicative and additive interaction models. Our study revealed that the cut-off values of the NLR and SIRI to predict the clinical outcomes were determined to be 6 and 4, respectively. NLR > 6 (OR 2.202, 95% CI: 1.094–4.430) and SIRI > 4 (OR 2.056, 95% CI: 1.065–3.968) were associated with increased risks for poor clinical outcomes at 1-month post-discharge. SIRI > 4 (OR 2.428, 95% CI: 1.389–4.243) were associated with increased risks for poor clinical outcomes at 3-month post-discharge. NLR > 6 (OR 1.978, 95% CI: 1.093–3.580) were associated with increased risks for poor clinical outcomes at 6-month post-discharge. The NLR and SIRI did not have an additive effect on the clinical outcome at 1-month post-discharge. Our findings indicate that high NLRs and SIRIs, particularly NLR > 6 and SIRI > 4, are associated with poor clinical outcomes in ICH stroke patients.