Association of Genetic Variants of Hemostasis System Genes With Pregnancy Lose in Women

Background. Venous thrombosis is etiopathogenetically associated with hereditary and acquired conditions characterized by an excessive tendency of the body to thrombosis in blood vessels. One of the types of disorders in the hemostasis system is gestational thrombophilia, which can lead to various pregnancy complications. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors. Objective . To analyze the association of 8 genetic variants of the hemostasis system genes in women with pregnancy lose (PL). Design and methods. The study included 311 women aged 20 to 38 years, who have had at least one pregnancy end in miscarriage, and 225 women in the control group. The study of the genotypes of the selected genetic variants was carried out by real-time PCR with melting curve analysis. Results. A positive association was found for 4 genetic variants: F2: 20210 G>A (OR=11.03, CI: 2.60 – 46.81, P<0.001); F5 1691G>A (OR=6.02, CI: 2.52 – 14.38, P<0.001); FGB: -455 G>A (OR=5.65, CI: 3.05–10.45, P<0.001) and PAI-1 -675 5G>4G (OR=2.28, CI: 1.54-3.39, P<0.001). Conclusion. Thus, we established an association of 4 genetic variants of plasma hemostatic factor genes with PL in women.