Determination of the Relationship between Hyperemesis Gravidarum and Systemic Inflammation Markers: A Case-Control Study

Background We planned our study to investigate the relationship between HEG and inflammation markers like NLR, PLR and MLR. Materials ant method: A total of 150 pregnant women diagnosed with HEG and 150 controls were included in our study. Data were analyzed for demographic variables, complete blood count results, and urinary ketonuria levels. Results We found NLR, PLR and MLR to be significantly higher in HEG patients than controls (p < 0.05), indicating a potential role of systemic inflammation in HEG pathophysiology. ROC analysis revealed moderate discrimination powers for these markers, suggesting their utility as adjunctive diagnostic tools in clinical settings. However, no correlation was found between inflammatory markers and the severity of ketonuria. Conclusions NLR, PLR and MLR values ​​can be used as indicator for HEG as a result of the inflammatory process in HEG group.