Prognostic biomarker GOLM1 correlated with immune infiltrates in Endometrial cancer

Background Endometrial cancer (UCEC) is a prevalent gynecological cancer that affects women’s reproductive organs. While studies indicate that GOLM1 may influence the immune response through the tumor microenvironment, its exact roles and mechanisms in UCEC are still not well understood. This study examines the varied expression levels of GOLM1 in UCEC and investigates the relationship between GOLM1 expression and the prognosis of patients with UCEC. Methods In this study, we analyzed data from the TCGA database. We utilized several bioinformatics methods, such as differential gene expression analysis, Kaplan-Meier survival analysis, gene set enrichment analysis, and immune cell infiltration analysis. These bioinformatics methods systematically integrate clinical data, gene expression, and immune information, offering a comprehensive view of the molecular mechanisms underlying UCEC.This study employed the software tools TCGA, GEPIA, TIMER, and MethSurv. Results GOLM1 mRNA levels were significantly elevated in UCEC tumor tissues. A strong association was found between GOLM1 expression and overall survival in UCEC patients. Enrichment analysis showed that GOLM1 is linked to several biological pathways, including dynein-bound intraflagellar transporters, fatty acid metabolism, and the transcriptional regulation of pluripotent stem cells. Based on these associations, GOLM1 likely plays an important role in the immune microenvironment of UCEC. Furthermore, GOLM1 expression may be influenced by DNA methylation. Conclusions GOLM1 is crucial for UCEC, as its levels significantly influence both the occurrence and progression of the disease. GOLM1 and its related genes are potential immunotherapeutic targets for UCEC. Additionally, DNA methylation may regulate the expression of GOLM1 in patients with UCEC.