Survival analysis in bloodstream infection patients

Objective To determine the risk factors that affect the mortality of patients with bloodstream infections in critical care settings. Methods The 2789 BSIs patient data were collected which were diagnosed by positive blood culture from 2013 to 2023 in our hospital, the pathogen, underlying disease, and infection source by cox survival analysis. Results The 2789 BSIs patient average mortality was 32.27%, 28day survival rate was 0.636 ± 0.012. E. coli was the most frequent pathogen accounting for 31.70% overall, followed by Klebsiella pneumoniae and S. aureus accounting for 14.33% and 11.26% respectively. Cancers were the frequent underlying disease accounting for 15.63% overall, followed by hematologic malignancy and uremia accounting for 14.49% and 6.10%respectively. Urinary tract infections (UTIs) were the first infection source accounting for 17.0% overall, followed by cholecystitis and cholangitis, pulmonary infection, and catheter-associated bloodstream infections (CABSIs) which accounted for 12.7%,11.9%, and 11.0% respectively. The mortality risk factors in BSIs patients were ICU, carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), Co-pathogen very significant difference ( p <0.01). Cox survival analysis in BSIs patients were pathogen of Candida, infection source of pulmonary infection, abdominal sepsis, intracranial infection, and enterogenic sepsis, underlying disease of cancers, hematologic malignancies, cerebrovascular disease, multiple traumas, pulmonary diseases, and digestive tract damage OR was <1.00, and p-value<0.01(95% confidence interval). Conclusion Factors affecting the survival of BSIs patients were pathogen of Candida, infection source of pulmonary infection, abdominal sepsis, intracranial infection, and enterogenic sepsis, underlying disease of cancers, hematologic malignancies, cerebrovascular disease, multiple trauma, pulmonary diseases, and digestive tract damage.