Association Between Estimated glucose disposal rate and Erectile Dysfunction in US Adults：a cross- sectional analysis of the NHANES 2001-2004

Background Erectile dysfunction (ED) is a sexual health issue affecting approximately 152 million men worldwide. Diabetes is a significant risk factor for ED, with insulin resistance playing a pivotal role in its pathogenesis. The Estimated Glucose Disposition Rate (eGDR), has been validated as a convenient and non-invasive indicator for assessing insulin resistance in diabetic patients. However, no studies have yet explored the relationship between eGDR and ED. Objective The purpose of this study was to determine the association between eGDR and ED in U.S. men from the National Health and Nutrition Examination Survey (NHANES). Design: The study analyzed data from 1,844 men aged 20 years and older in the 2001–2004 NHANES. Multivariate logistic regression with sampling weights assessed the association between eGDR and ED. Smoothed curve fitting were employed to explore the linearity of the eGDR-ED relationship. Subgroup analyses and interaction tests were performed to ensure the robustness of the result. Result We found a negative connection between eGDR and ED in men. Each unit increase in eGDR is associated with a 22% reduction in the risk of ED [odds ratio (OR) = 0,78 ,95% confidence interval (95% CI): 0.72–0.85, P < 0.0001]. Conclusion Estimated glucose disposal rate was related to risk of Erectile Dysfunction in the United State adults, increase in eGDR is associated with a reduction in the risk of ED.