Head and Neck Squamous Cell Carcinoma: Novel Therapeutic Targets Uncovered by Integrative Analysis of Genetic Susceptibility and Spatial Transcriptomics
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Head and neck squamous cell carcinoma (HNSCC) presents a significant worldwide burden and with a poor prognosis. Nevertheless, the molecular characteristics of cancer cells remain inadequately investigated. This study integrated single-cell RNA sequencing (scRNA-seq), mendelian randomization (MR), and spatial transcriptomic analysis to explore hereditary factors and critical gene expressions. Data were sourced from public databases. Our findings revealed significant associations of genes PODXL2, SNTA1 with HNSCC, acting distinct roles in pathways as muscle contraction. Spatial transcriptomics pinpointed localized gene expression variations across 8 tissue samples, with pseudo-time analysis capturing cellular developmental trajectories. Drug sensitivity testing further identified candidate therapeutics. This work provides a multi-modal approach to identify molecular landscape and potential targets in HNSCC.
