The role of omega-3 fatty acid supplementation on glycemic control and lipid profiles in reproductive-aged women with pre-diabetes.

Background: Prediabetes is a precursor to type 2 diabetes and healthy interventions results in delay or postponing. To evaluate the benefits of omega-3 fatty acid supplements in reducing glycemic and lipid profiles in reproductive-aged women with Prediabetes. Material and Methods - This is a Randomized placebo Controlled Trial conducted on 90 patients at a tertiary Hospital and Research Centre, in India. After randomization one group (n=45) received placebo and the other received (n=45) Omega3 fatty acid supplement (1000mg) twice daily. Blood samples were collected from all participants in the morning after 12 h of fasting for lipid profile. The insulin resistance was determined using the homeostatic model assessment of insulin resistance (HOMA-IR) index, and the beta-cell function using the HOMA-B index. Results - After a follow-up perid of three months subsequent to the drug intervention, the average FBS showed a significant reduction to 99.5 ± 8.6 (p <0.0001) in post group. Conversely, there was no notable alteration observed in the average PPBS, HbA1c, and fasting insulin levels, the mean HDL, LDL, VLDL, between the Pre and post groups. The average HOMA-IR and average TGL were decreased in the Post group (p <0.0001). Conclusion - In the present study omega 3 fatty acid supplementations improved fasting blood sugar, triglycerides and HOMA-IR in reproductive-aged women with pre-diabetes. Considering the impact of Prediabetes in reproductive health and its outcome, omega-3 supplementation, therefore, can be recommended as a therapeutic option for glycemic control in these individuals.