Aneurysmal Subarachnoid Hemorrhage Risk Assessment Model Identifies Patients for Safe Early Discharge at Day 15 – The SAFE-SaHScore

Background Patients with aneurysmal subarachnoid hemorrhage (aSAH) are often hospitalized for 21 days after aneurysm rupture due to the risk of complications. However, some never experience complications and are unlikely to benefit from a prolonged hospitalization. Objective The aim of this study is to derive a risk assessment model (RAM) using data from the first 14 days of hospitalization to identify low-risk patients for early discharge, at day 15 or after. Methods Patients > 18 years old with an acute aSAH at a Comprehensive Stroke Center from 2017–2024 were included. Baseline demographics, aSAH grading scales, and in-hospital complications requiring intervention were characterized. Complications included: vasospasm, delayed cerebral ischemia (DCI), cerebral salt wasting (CSW), cerebral edema, seizures, arrhythmias, respiratory failure, and hydrocephalus. Binary logistic regression with leave-one-out cross validation (LOOCV) was used to identify an optimal RAM. Results Of 165 patients, the mean Hunt Hess Score (HHS) was 2.5 (SD 1.2), modified Fisher Score (mFS) was 3.1 (SD 1), endovascular therapy was used for aneurysm securement in 73%, and 54.5% experienced complications during days 15–21. In bivariate analyses, days 0–14 variables associated with days 15 + complications were: HHS, mFS, middle cerebral artery (MCA) aneurysm, clinical or radiologic vasospasm, endovascular therapies, intraventricular hemorrhage, hydrocephalus, external ventricular drain (EVD), mechanical ventilation, vasopressors, hypertonic solutions, antiseizure medications, milrinone, and fludrocortisone (all p < 0.05). LOOCV regression for a best fit RAM included 6-variables: S um - of vasopressors, A rtery - MCA aneurysm, F ludrocortisone, E VD, S cale - modified Fisher Score and H unt and Hess Score [ SAFE-SaH ], and had an AUC = 0.90 (0.85–0.95), sensitivity = 0.94, specificity = 0.69, PPV = 79%, and NPV = 91% for predicting complications on day 15+. Conclusions This is the first ever RAM to incorporate clinical data from the first 14 days of hospitalization to identify aSAH patients at low risk for complications after day 14. With 94% sensitivity, the RAM classifies patients who will not have complications and may assist in earlier disposition on day 15 or after.