Global, Regional, and National Burdens of Ischemic Heart Disease attributable to air pollution from 1990 to 2030

Over the period 1990-2021, this study analyzes the global distribution and changes in the burden of ischemic heart disease due to air pollution. According to global disease burden data from 204 countries and regions between 1990 and 2021, this study analyzes ischemic heart disease (IHD) deaths and disability-adjusted life years (DALYs) related to air pollution. The global burden of IHD attributable to air pollution has generally decreased over the past 30 years, with estimated annual percentage changes of -1.37 (-1.46, -1.28) for age-standardized mortality rates and -1.31 (-1.4, -1.22) for age-standardized DALYs. In higher-earning countries, burden levels are declining, while in North Africa, the Middle East, South Asia, and East Asia, burden levels are increasing. In terms of age-standardized DALYs rates（ASDRs）, men have a higher burden than women, with those aged 50-75 experiencing the greatest burden. There is a nonlinear, inverted V-shaped relationship between sociodemographic index and ASDRs for IHD.The global burden, as well as the burden in the five SDI regions, is projected to continue declining over the next decade.As a result of air pollution, many countries and regions have experienced a decrease in the burden of IHD in the past 30 years.However, in some low-income nations, particularly among men and populations between middle age and old age, the burden remains severe.Focusing on targeted populations is crucial to mitigate the burden of IHD, particularly in areas where mortality and disease burden are increasing.