Glucose and Lipid-Lowering Activities of Some Bioactive Extracted Components from Herbs (Camellia Sinensis, Matricaria Chamomilla and Carum Carvi) in Streptozotocin-diabetic Rats: Intelligent Method for Herbal Medicines Production with Selected Active Ingredients
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Diabetes mellitus (DM, Type 2 diabetes) is a metabolic syndrome categorized by irregular discharge of insulin that subsequently disturbs glucose breakdown. It is the most prevalent chronic non-communicable increasing disease globally and has a great impact on human health. Many treatments have been recently proposed for this disease like insulin and medicine therapies. However, some of these treatments have shown slight efficacy practically with many side effects, thus, searching for new classes of natural and safe compounds has a global demand. Based on the many reported pharmacological effectivity of Camellia Sinensis, Matricaria Chamomilla, and Carum Carvi , evaluation of the glucose and lipid-lowering properties of some extracts of such plants by some polar and nonpolar organic and aqueous solvents in streptozotocin-diabetic mice and rats were done in the research. The results showed that some extracts of Camellia Sinensis, Matricaria Chamomilla , and Carum Carvi can properly lower serum glucose and reverse inappropriate changes regarding serum lipids including triglyceride, cholesterol, HDL-cholesterol, aa well as LDL-cholesterol in diabetic experimental animals. To conclude, all of these herbal remedies with multiple bioactive components are of potential benefit in the management of diabetes mellitus.