Research on Hyaluronic Acid/Polyethylene oxide Electrospun Fiber Membranes for Skin Defect Repair

Skin tissue defects are a common clinical issue. Electrospun nanofibrous membranes, mimicking the extracellular matrix (ECM) structure, show promising potential for skin defect repair. This study utilizes electrospinning technology to prepare a soft, lightweight, and breathable fibrous membrane wound dressing using hyaluronic acid and polyethylene oxide as substrates for skin defect repair. Scanning electron microscopy (SEM) measurements reveal an average diameter of 280.7 ± 10.24 nm for the fibers. The study evaluates the fibrous membrane's absorbance, hydrophilicity, porosity, water vapor permeability, and antibacterial property.and assesses wound healing and histological outcomes through in vivo experiments. The hyaluronic acid/polyethylene oxide (HA/PEO) combination demonstrated an excellent 92.53±2.32% wound healing rate and the thickest connective tissue thickness of (1597.04± 272.71μm) µm on day 14, along with the highest collagen area deposition （33.20 ± 5.58% ）. These results indicate that the hyaluronic acid/polyethylene oxide fibrous membrane exhibits excellent mechanical properties, hydrophilicity, biocompatibility, and significant potential for promoting wound healing.