Structural and Vascular Assessment of the Optic Nerve Head and Macula in Chronic Chagas Disease

Chagas disease (CD), a parasitic infection, may have ocular repercussion in its cardiological form, since history of heart disease of other etiologies has already been established as a risk factor for neuropathies and maculopathies. The aim of the present study was to investigate preclinical structural and vascular optic nerve head (ONH) and macular parameters in chronic CD patients. Chagasic patients and healthy subjects (n = 19) were evaluated with optical coherence tomography, optical coherence tomography angiography and Laguna ONhE® software. The main outcome measures were the glaucoma discriminant factor, average peripapillary retinal nerve fiber layer thickness, ganglion cell complex thickness, peripapillary vascular density (VD), foveal and parafoveal thickness, foveal avascular zone area, and total foveal and parafoveal VD from the superficial and deep capillary plexus that were compared between the two groups. No significant differences were observed among the studied variables. Although our findings suggest that the cardiovascular dysfunction resulting from chronic CD does not seem to cause significant structural or vascular preclinical changes to the ONH and the macula, the results herein can benefit the chagasic population and provide important information about the progression of the disease and its systemic complications.