Global Burden Of Chronic Kidney Disease Due To Hypertension From Year 1990 To 2021 and Implications From Disparities Across Regions

Background: Chronic Kidney Disease due to hypertension poses a growing global diseaseburden, with significant disparities across regions. Comprehensive analysis and effective strategies should be provided to tackle the increasing issue. Methods: Using data from the Global Burden of Disease 2021, this study conducted descriptive and statistical analyses to evaluate the CKD burden due to hypertension across different SDI regions. EAPC,risk factors and decomposition were used to analyse the tread and distributional difference Findings: Globally, ASMR increased from 4.29 (95% UI: 3.55–5.11) per 100,000 in 1990 to 5.54 (95% UI: 4.68–6.41) in 2021, with a 0.97% annual increase. High SDI regions saw a sharp rise, with ASMR climbing from 2.4 (95% UI: 1.95–2.86) to 4.09 (95% UI: 3.34–4.71) and an EAPC of 2.23%. Low SDI regions experienced a slight decline in ASMR from 8.69 (95% UI: 7.03–10.73) to 8.62 (95% UI: 7.09–10.51). High systolic blood pressure and kidney dysfunction have consistently been the leading risk factors, female have a higher risk of high body-mass index than men, especially in high SDI regions.Decomposition highlights aging and epidemiological shifts，East Asia demonstrated a unique trend, with a 49.59% reduction in ASMR, ASDR and ASPR despite an aging population, reflecting successful interventions.