Diagnostic Accuracy of Combined T2-weighted MR Imaging and H1MR Spectroscopy for Prostate Cancer Detection

Background The primary objective was to evaluate the diagnostic accuracy of combining T2-weighted MR imaging and H1MR Spectroscopy in detecting prostate cancer, with histopathology serving as the reference standard. Methods The study included 125 male patients aged 44–78, who presented with clinical suspicion of prostate cancer (e.g., gland asymmetry, nodule, induration, adhesion, or palpable seminal vesicles). Patients with previous surgeries, hormonal or radiation therapy, or a biopsy within the last 12 weeks were excluded. MR imaging and H1MR Spectroscopy were conducted using a 1.5 Tesla scanner, and histopathology was used as the gold standard. Results The mean patient age was 63.17 ± 8.47 years. Of the 125 patients, 54 were true positives, 7 were false positives, 49 were true negatives, and 15 were false negatives. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 78.26%, 87.5%, 88.52%, 76.56%, and 82.4%, respectively. Conclusion The combination of T2-weighted MR imaging and H1MR Spectroscopy demonstrates high diagnostic accuracy in detecting prostate cancer. This technique, pending further validation, may serve as a reliable non-invasive diagnostic method in clinical practice.