The relationship between ambulatory blood pressure and atherogenic index with LV geometry pattern in obese children: results from a cross-sectional study in Serbia
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Background. Arterial hypertension and increased atherogenic index of plasma (AIP) are strong predictors of cardiovascular risk associated in individuals with obesity both in adults and children. Thus, we aimed to explore the relationship between AI and ambulatory blood pressure index (ABPI) with left ventricular geometry pattern in obese children. Methods. In this cross-sectional study, a total of 129 obese children (BMI greater or equal to the 95th percentile for age and sex) were examined. Fasting blood samples were taken to measure plasma glucose level, lipid profile, including total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and insulin level. Two-dimensional (2-D) transthoracic echocardiography was performed to determine left ventricular geometry pattern. Ambulatory blood pressure recording was obtained for 24 hours in all obese children. Linear regression analyses were conducted to explore relationships between AIP (calculated as logarithmic transformation of the ratio of TG to HDL-C) and ABPI with left ventricular myocardial mass index (LVMI) and relative wall thickness (RWT). We also used sex as a potential effect modifier, and calculated stratum-specific estimates of the effect. Results : We demonstrated independent and positive association of age and AI with RWT (Age: effect size = 0.83 CI 0.22–1.45) p = 0.008; AI effect size 8.9 (CI 3.6–14.3); p = 0.01). In a subgroup analysis with sex as an effect modifier, independent positive association of borderline significance at p = 0.011 was found between AI and RWT only in boys AI: effect size 9.5 (CI 2.3–16.7) p = 0.01 LVMI was significantly associated with sex and BMI (sex: effect size = 6.8 CI (2.6–11) p = 0,002; BMI z score: effect size = 6.8 CI (3.2–10.4) p < 0.001. Independent positive association was also found between BMI and LVMI for girls, effect size = 11.9 (CI 4.1–19.8) (p = 0.005). Conclusion : AI and age are independently associated with the presence of concentric left ventricular geometry with girls seeming more protected from atherogenic hypertrophic stimulus than boys. BMI and sex are independently associated with eccentric left ventricular remodeling, with BMI being a greater risk factor for girls.