The role of COX-2 in Knee osteoarthritis: a comprehensive analysis of cytokines, inflammation, and signaling pathways
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Knee osteoarthritis (KOA)of the knee is a prevalent joint disorder closely associated with multiple factors, among which cyclooxygenase-2 (COX-2) plays a pivotal role in inflammatory responses and cytokine release. This review aims to elucidate the role of COX-2 in the pathogenesis of knee osteoarthritis, analyze its interplay with key cytokines, and examine the signaling pathways involved in this process. By employing immunohistochemical techniques, we intend to gain a deeper understanding of the expression patterns of COX-2 and its functions within the inflammatory microenvironment, thereby providing new insights for the treatment of knee osteoarthritis.