Angiogenesis-Enhanced Biomimetic Nanofiber Dressings: VEGF-Infused Electrospun Membranes for Targeted Wound Healing and Tissue Regeneration

Biomimetic dressings are widely regarded as optimal medical dressings for promoting wound healing. Researchers are endeavoring to develop a new class of dressings that can fend off bacterial infections, accelerate tissue regeneration, and perform specialized tasks to facilitate wound healing and repair. This study presents an electrospinning nanofiber membrane-building approach based on natural biopolymers and the addition of vascular endothelial growth factor (VEGF) to boost angiogenesis and promote wound healing. The composite nanofiber membrane made using the electrospinning technique can retain its physicochemical properties and biological function. It has strong biocompatibility and is appropriate for wound repair because of its improved mechanical and biomedical qualities. The designed nanofiber membrane regulates the release of highly concentrated VEGF to target the wound specifically. It facilitates the interchange of nutrients and oxygen, encourages endothelial cell migration and proliferation, and forms the vascular lumens, all of which help to speed up tissue regeneration and wound healing. As a result, VEGF@PAG nanofiber dressings have the potential to overcome the drawbacks of conventional patches and emerge as the most beneficial alternatives for wound healing and associated biological applications.