Shedding suppresses receptor-ligand trogocytosis to enhances long-term antitumor potential
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Trogocytosis is a curious phenomenon in which the rapid transfer of cell-membrane proteins between cells is induced by receptor-antigen ligation. In Chimeric antigen receptors therapy, the target antigen is transferred to T cells via trogocytosis, thereby decreasing the target density on tumor cells and abating the T cell activity. The result is tumor immune escape and T cell fratricide, two factors known to cause relapse after Chimeric antigen receptors therapy. Here we report receptor shedding as a mechanism to suppress trogocytosis. The shedding structure of Chimeric antigen receptors corresponded with the trogocytosis and long-term antitumor effect. This link between trogocytosis and shedding indicates a previously unknown form of communication between proximal cells.
