Investigating the behavioral and antioxidative effects of ethanolic extract from Schumanniophyton magnificum (K. Schum) in ketamine-induced mice.

This work presents an investigation on the behavioral and antioxidative effects of ethanolic extract from Schumanniophyton magnificum (K. Schum) in mice . Psychosis has several detrimental effects on health, as a result, a therapeutic strategy for managing psychosis is crucial to maintaining the global community’s health because when mental illness comes up in the human brain it’s reflected through different display of behavior like slow reasoning ability, depression, memory loss and isolating of oneself from others. However, it is not known whether Schumanniophyton magnificum leaves could cure or prevent psychosis because no study has ever cover the aspect of this plant nor any ethnobotanical study done on its activity in managing psychosis, thisfurther emphasizes the urgency for innovative treatment approaches. The plant was administered through oral route to group of ketamine induced mice at a dosages of 100, 200 and 400 mg/kg; compared with controls group of mice for 14 days. The behavioral assessment was demonstrated using the Open Field Test for assessing the ketamine-induced hyperlocomotion, Y-Maze test was used for assessing the behavior, learning and memory (cognition) and novel object recognition test to evaluate the willingness of the mice to explore new environment or object in animal models of the central nervous disorders. Thereafter, some biochemical assay were conducted. This research shows that after 14 days of administration, the animals were sacrificed and antioxidant bioassay was carried out on the brain. Schumanniophyton magnificum treatment significantly (P < 0.05) reduced hyper-locomotion induced by ketamine, which is a predictor of positive symptoms. Schumanniophyton magnificum treatment (100 and 400 mg/kg) significantly enhanced spatial memory formation preventing cognitive deficits by ketamine. Schumanniophyton magnificum treatments significantly increased the SOD & CAT activities, as well as decreased MDA levels, this is suggesting that the antipsychotic-like action of Schumanniophyton magnificum maybe through inhibition of oxidative crises induced by ketamine. This study could potentially pave new way for cost-effective interventions that address both the health and socioeconomic burdens associated with psychosis.