A comparison of genomically enhanced breeding values predicted by different single-step approaches

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Abstract

Many countries are currently adopting the single-step model for national genetic evaluations of dairy cattle. The two most widely applied statistical formulations of the single-step model are Genomic Best Linear Unbiased Prediction (G-BLUP) and Single Nucleotide Polymorphism BLUP (SNP-BLUP), with the main difference being the handling of additive genetic covariance between individuals with genotypes. Using solvers available in the MiXBLUP software, our study aimed to compare both models regarding the quality of Genomically Enhanced Breeding Value (GEBV) prediction, bull rankings, and computational efficiency (memory consumption and computational time). The results demonstrated no marked differences in the quality of GEBV prediction expressed by the metrics underlying the Interbull validation, except for the G-BLUP, APY-based solvers with 3,000 core bulls. However, the ranking of the top 50 bulls differed between models, which has implications for the breeding industry and selection, since the top-ranking bulls are typically the most widely used. 39 and 31 of the top 50 bulls were common to all models for stature and foot angle, respectively. In terms of computational time, SNP-BLUP and G-BLUP with APY solver using 3,000 bulls were the fastest, the GT G-BLUP solver was the slowest. The selection of core individuals for the APY solver was a crucial element that affected the prediction accuracy. Still, the use of the GT G-BLUP or the SNP-BLUP solver can circumvent this issue since no selection of core individuals is required.

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