A Comparative Case Study of Pituitary Macroadenoma Treatment: No Intervention, Medication, Nutrition, and Endoscopic Transsphenoidal Surgery

This paper presents a detailed case report of a 19-year-old woman diagnosed with hyperprolactinemia, followed over a six-year period until her full recovery at age 25. The patient’s initial complaint of ineffective laser hair removal led to the discovery of elevated prolactin levels, followed by a diagnosis of polycystic ovary syndrome (PCOS). Despite undergoing multiple pharmacological treatments, including Bromocriptine and Cabergoline, the patient developed secondary amenorrhea and was diagnosed with a treatment-resistant pituitary macroadenoma. Dietary modifications and herbal supplements provided only temporary relief. Ultimately, surgical intervention via endoscopic transsphenoidal surgery successfully resolved the patient’s condition, with normalized prolactin levels and the resolution of amenorrhea. This case highlights the challenges of managing treatment-resistant hyperprolactinemia and underscores the importance of adaptable treatment plans and the potential necessity of surgery.