Adipocytokine levels in Chronic Periodontitis and Type 2 Diabetes Mellitus after Nonsurgical Periodontal Therapy

Objective : A thorough meta-analysis was used to assess the levels of 4 adipocytokines in the gingival crevicular fluid(GCF) of individuals with chronic periodontitis (CP) linked to Type 2 Diabetes Mellitus (T2DM) before and after non-surgical periodontal therapy (NSPT). Sources : PubMed, Scopus, and EBSCOhost databases were exhaustively searched. Study selection : The three databases and Gray literature were searched for studies that fit the inclusion and exclusion criteria. The Joanna Briggs Criteria were used to assess the study's level of quality. The meta-analysis was performed for the GCF levels of adipocytokines and clinical parameters clinical attachment level(CAL), gingival index(GI), periodontal Index(PI), periodontal probing depth(PPD) to further analyze the effect of the NSPT on the same. After thoroughly reviewing the full texts, abstracts, and removal of duplicates, seventeen papers were identified and included for systematic analysis. Upon further critical evaluation, only seven publications qualified for the meta-analysis. The levels in the test and control groups were analyzed using meta-analysis since the results were in mean + standard deviation. Conclusion : The results indicate that nonsurgical periodontal therapy significantly reduces the levels of adipocytokines in GCF of patients with CP and T2DM. Further, there is a significant improvement in the clinical parameters of periodontal disease after NSPT.