Antimicrobial Drug Sensitivity Pattern of Staphylococcus Aureus Isolated at Ringroad State Hospital, Ibadan.

Staphylococcus aureus is a gram-positive, catalase-positive, coagulase-positive bacteria. They are known to be the causative agent of various infections, including pyogenic infections, impetigo, urinary tract infections, food poisoning, septicemia, meningitis, and osteomyelitis. Staphylococcus aureus, like every other bacterium, is resistant to antimicrobial drugs and continues to defend against medical control and empirical treatments for infections caused by this microorganism; thus, there is a need for antimicrobial sensitivity testing to determine the appropriate drugs for the treatment of staphylococcal infections. This study investigated the antimicrobial drug sensitivity pattern of Staphylococcus aureus isolated from clinical samples at Ring Road State Hospital, Ibadan. One hundred thirty-two (132) isolates were obtained from clinical samples and were confirmed as S. aureus. Thereafter, the antimicrobial sensitivity test was performed via the Kirby–Bauer disc diffusion method. The sensitivity of each of the isolates was as follows: 92.4% of the isolates were resistant to amoxicillin, 88.6% were resistant to Zinnacef, and 65.9% were resistant to Pefloxacin. In addition, 65.2% of the isolates were resistant to Rocephin, and 56.8% of the isolates were resistant to methicillin. Most of the isolates were sensitive to ciprofloxacin (65.2%), streptomycin (56.8%), and erythromycin (50.8%). Antimicrobial drugs such as amoxicillin, Zinnacef, pefloxacin, rocephin, and methicillin were shown to be less likely to be effective in the empirical treatment of staphylococcal infections. In the study region, however, ciprofloxacin, streptomycin, and erythromycin are recommended as first-line antibiotics for the empirical treatment of staphylococcal infections. Statistical analysis revealed that age and sex had no influence on the sensitivity pattern of the isolates to amoxicillin, ciprofloxacin, pefloxacin, rocephin, streptomycin, erythromycin, or methicillin, whereas sex influenced the sensitivity pattern of the isolates to gentamycin and Zinnacef. This study underscores the importance of surveillance of Staphylococcus aureus antibiotic sensitivity patterns to select appropriate therapies, the need to effectively monitor and improve antimicrobial policies, and funding for appropriate research and therapy for Staphylococcus aureus in the health sector.