The Predictive Value of Myoglobin for Sepsis-Induced Cardiomyopathy

Myoglobin (MYO) levels can be detected in the early stages of sepsis and may serve as a potential biomarker for assessing the severity and prognosis of sepsis. Our study aims to explore the predictive value of MYO for sepsis-induced cardiomyopathy (SICM) in patients with sepsis. A single-center prospective cohort study was conducted, collecting demographic data, admission Sequential organ failure assessment (SOFA) scores, echocardiography results, MYO, N-terminal pro-B-type natriuretic peptide (NT-proBNP) results, and other related records from 158 patients with sepsis. Patients were divided into SICM and non-SICM groups based on the left ventricular ejection fraction (LEVF) results from echocardiography. Propensity score matching (PSM) was used to control for the confounding effects of age, gender, and BMI. Univariate and multivariate Logistic regression analyses were performed to identify factors associated with the occurrence of SICM; the receiver operating characteristic (ROC) curve was used to evaluate the predictive ability of MYO for SICM. MYO levels were higher in the SICM group than in the non-SICM group (395.7 ng/ml vs 108.7 ng/ml, P < 0.05). Multivariate binary Logistic regression analysis showed that MYO is an independent risk factor for SICM in patients with sepsis (95% CI = 0.580–0.782, P < 0.05), with an area under the ROC curve (AUC) of 0.681 (95% CI: 0.580-0.782). MYO has good predictive value for SICM in patients with sepsis.