Effect of Different Doses of Ciprofol on Hemodynamics Induced By General Anesthesia in Elderly Diabetic Patients Undergoing Spinal Surgery: A double-blind, randomized, controlled study

Objective To investigate the safety and efficacy of different doses ciprofol in induction of general anesthesia in elderly diabetic patients. Methods Ninety spinal single-level PLIF patients who were planned to undergo elective tracheal intubation under general anesthesia were selected as the subjects.The study subjects were randomly divided into 3 groups. Ciprofol induction dose was 0.2 mg/kg in group A, 0.3 mg/kg in group B and 0.4 mg/kg in group C, The safety and efficacy of general anesthesia induction were compared among the three groups. Results The incidence of hypotension in group C (46.4%) was significantly higher than that in group A (7.4%) and group B (14.8%) (P < 0.05). AUCMAP of the three groups was higher in group C (176.39±33.83 mmHg.min) than in group B (158.44±26.55 mmHg.min) and higher in group B than in group A (143.59±19.52 mmHg.min), P < 0.05. The incidence of intubation reaction in group A (77.8%) was the highest (P < 0.05). There were significant differences in BIS values at 3, 4 and 5 minutes after administration. Conclusion The use of 0.3mg/kg ciprofol in the induction period in elderly diabetic patients has more stable circulation and less vasoactive drug dosage during induction, which is better than 0.2 and 0.4mg/kg dosage groups. The trial was registered at Chinese ClinicalTrials.gov in February 26, 2024 (Registration number:ChiCTR2400081164).