Unveiling Biomarkers: A Study on Mitocytosis-Related Genes Across Multiple Cancers

Mitochondria are crucial organelles in eukaryotic cells that maintain cellular homeostasis through various quality control mechanisms. One such mechanism, mitocytosis, is newly identified, yet its biological significance in cancer remains unclear. This study investigates the role of mitocytosis-related genes (MYO19, KIF5B, DNM1L, DYNLL2, TSPAN4, TSPAN9) in pan-cancer. We performed an extensive analysis of expression profiles and clinical data derived from samples in The Cancer Genome Atlas (TCGA) database. This study entailed a comparison of gene expression between malignant and normal tissues, an investigation into the correlation between gene expression and clinical prognosis through Kaplan-Meier and Cox regression analyses, and a functional enrichment analysis to elucidate the potential signaling pathways involved. We employed TIMER2.0 to assess the correlations between gene expression and immune infiltration levels in various cancers.Additionally, a nomogram predicted three- and five-year overall survival rates. The study also examined the influence of CTLA-4 and PD-1 statuses on Immunoscore (IPS) in KIRC patients, revealing that these genes are overexpressed in renal clear cell carcinoma and significantly associated with Clinical prognosis and drug response.