Active Surveillance Follow-Up for Prostate Cancer: From Guidelines to Real-World Clinical Practice

Purpose To assess active surveillance (AS) adherence for prostate cancer (PCa) in a “real-world” clinical practice. Materials and Methods We utilized our institutional database which was built by interrogating electronic medical records for all men who got diagnosed with PCa from 1995 to 2022. Our cohort included all patients aged < 76 years, with PCa Gleason Grade (GG) 1 or 2, ≤ cT2c, PSA ≤ 20 ng/ml at diagnosis, enrolled on AS, and with at least one biopsy after diagnosis. Patients were separated into two groups based on the monitoring intensity.Patients with at least 1 PSA/year and at least 1 biopsy every 4 years were categorized as adherent to guidelines. Univariable and Multivariable logistic regression analyses were used to examine the impact of covariates on non-adherence to guidelines. Competing risks cumulative incidence was used to depict PCSM. Results A total of 546 men met the inclusion criteria. Overall, 63 (11%) patients were adherent to guidelines (Group 1), while 483 (89%) were not (Group 2). Median PSAs/year and median biopsies/year were 2.3 (2.0-2.7) and 0.4 (0.3-0.6) for Group 1, and 1.2 (0.7-1.8) and 0.2 (0.1-0.2) for Group 2, respectively (both p<0.0001). At multivariable analysis, Black men had a 2.20-fold higher risk of being in Group 2 than White men (p<0.05). Patients with cT2 (OR:0.24, CI:0.11-0.52) and those with CCI ³2(OR:0.40, CCI:0.19-0.82) were less likely to be in Group 2, when compared to cT1 stage and CCI=0, respectively (both p< 0.05). At 10 years, the cumulative incidence estimate of prostate cancer-specific mortality (PCSM) for the entire cohort was 2.1%. Conclusion We found substantial deviations from AS monitoring guidelines, particularly in biopsy frequency, which did not seem to compromise PCSM in patients with stable PSA. Notably, our findings suggest that strict adherence to guidelines, especially in patients with cT2 at diagnosis, remains crucial.