Genetic Susceptibility and Disease Activity in Ankylosing Spondylitis: The Role of GPR35 rs4676410 Polymorphism in a Turkish Population

Introduction : In East Asians, an additional genome-wide association study finally detected several new immune-related susceptibility loci for AS. There have been some investigations conducted for genetic variations, and it was found that the single nucleotide polymorphisms of GPR35 gene would play an important role in the pathophysiology of AS. The primary goal of the study was to explore the role of the rs4676410 polymorphism in the GPR35 gene in contributing to the susceptibility to Ankylosing Spondylitis (AS) and its influence on clinical and biochemical outcome parameters within the Turkish population. The study also aimed to understand how these genetic factors interact with the disease's pathogenesis and severity. Methods: We isolated DNA and examined the rs4676410 variation in GPR35 among 200 participants (100 with AS individuals and 100 with healthy individuals) by using real time PCR. Compared the results with biochemical data and then we evaluated results using IBM SPSS 26. Results: Our research has shown that having the AA genotype or A allele seems associated with a susceptibility or risk of developing AS in Turkish population. Conclusion: The strong correlational basis between disease-activity scores and genetic variants supports the utility of exploring genetics, which underscores as one of main player affecting parametric severity evaluations. This is the first study conducted in Turkey.