MicroRNA-513b-5p Contributes to the Development of Osteosarcoma via Inhibiting Sirtuin 1

  1. Tao Zhong
  2. Jinghang Lv
  3. Bowen Zheng
  4. Xiaowei Dong
  5. Lianbo Yang
  6. Zhiqiang Ye
  7. Haidong Liang
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Abstract

Objective The objective of this research was to clarify the role of miR-513b-5p in osteosarcoma (OS). Methods In OS cells, the miR-513b-5p expression was determined, and the impact of miR-513b-5p on malignant phenotypes of MG-63 cells was investigated. Moreover, the association between miR-513b-5p and sirtuin 1 (SIRT1) was studied. Results In OS, miR-513b-5p expression was reduced. Enhancing miR-513b-5p expression significantly reduced the proliferation, invasion, and migration of MG-63 cells. SIRT1 was one of the targets of miR-513b-5p, and overexpression of SIRT1 reversed the inhibitory effects of miR-513b-5p mimic on the malignant characteristic of MG-63 cells. Conclusion miR-513b-5p functions as a tumor suppressor in OS by inhibiting SIRT1. The therapeutic strategies targeting the miR-513b-5p/SIRT1 axis may improve the clinical outcomes of OS.

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  1. Version published to 10.21203/rs.3.rs-4976328/v1 on Research Square