Green Synthesis of Silver Nanoparticles using Alkanna Tinctoria Aqueous Leaf Extract and its Antibacterial and Antioxidant Activity Against Cancer Cell Lines
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Nanotechnology plays a pivotal role in advancing materials science, particularly through the development of nanoparticles, which are integral in a variety of industrial applications. This study focuses on silver nanoparticles (AgNPs), which are highly valued in multiple sectors due to their unique physical, chemical, and biological properties. We explore the green synthesis of AgNPs using the aqueous leaf extract of “ Alkanna tinctorial ”. This method not only ensures a sustainable and eco-friendly approach but also facilitates the production of nanoparticles with controlled sizes and shapes, which are crucial for their efficacy and application versatility. The synthesized AgNPs were characterized using advanced techniques including X-ray Diffraction (XRD), UV-visible Spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FT-IR), and Transmission Electron Microscopy (TEM). These characterizations confirm the successful synthesis and desired physicochemical properties of the AgNPs. The research highlights the broad applications of these AgNPs, demonstrating significant antimicrobial properties and potential anticancer activities. The nanoparticles showed a notable efficacy against a range of bacterial strains and exhibited promising anticancer properties in vitro, particularly tested against the HepG2 cell line. The AgNPs induce apoptosis and inhibit cellular proliferation, showcasing their potential as therapeutic agents in medical applications. This study substantiates the potential of biogenically synthesized AgNPs to serve as a safer, more efficient alternative to conventional nanoparticles, offering significant advantages in healthcare and beyond, owing to their tailored functionalities and reduced toxicity. The findings promote further exploration and development of green synthesis methods in nanoparticle production, ensuring sustainability and broad applicability in modern technology and medicine.
