Impact of mean platelet volume to lymphocyte ratio on short-term clinical outcomes in patients with acute ischemic stroke
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Background The Mean platelet volume-to-lymphocyte ratio (MPVLR) is an emerging and cost-effective biomarker that integrates MPV and lymphocytes, reflecting both thrombotic activity and inflammatory responses. Despite its potential, relatively few studies have explored the relationship between MPVLR and the prognosis of acute ischemic stroke (AIS). This study aims to investigate the correlation between MPVLR and short-term clinical outcomes in patients with AIS, providing insights into its prognostic significance. Method Data were collected from patients with AIS admitted to the Neurology Department of Beijing Shunyi District Hospital from January 2022 to August 2022. Patients were consecutively included and followed up three months post-symptom onset. The analysis of multivariable logistic regression was used to explore the association of MPVLR with poor functional outcomes. Additionally, a receiver operating characteristic (ROC) curve was analyzed to examine the predictive value of MPVLR. Results In this study enrolling 362 AIS patients, the MPVLR was found to be substantially higher in the group with poor outcomes compared to the group with good outcomes (P < 0.05). Patients in the lower tertile group had lower mRS scores (P < 0.05). In addition, previous stroke or TIA, MPVLR, and NIHSS scores at admission were identified as significant predictors of poor outcomes three months after AIS. The ROC curve revealed that the optimal cutoff value for MPVLR to predict poor outcomes at three months was 5.547. And the area under the curve for MPVLR was 0.727 (95% CI: 0.672–0.783), with a sensitivity of 82.2% and a specificity of 52.9%. Conclusions Elevated MPVLR values at admission were significantly correlated with short-term poor functional outcomes in AIS patients.