Global Burden and Epidemiological Trends of Common Pediatric Neurologic Disorders, 1990-2019

Objective: To report the latest estimates of pediatric neurologic disorders by sex, age, geography and sociodemographic index from 1990 to 2019. Methods： Thirteen major pediatric neurologic disorders were systematically analyzed by sex, year, age and region according to data from Global Burden of Disease Study 2019. The global burden was calculated based on deaths, prevalence, incidence, and disability-adjusted life-years (DALYs) from 1990 to 2019. Results: In 2019, global burden of pediatric neurologic diseases was responsible for 14.50% all-cause deaths and 13.82% DALYs in people under 20. The most burdensome diseases were noncommunicable disorders neonatal encephalopathy (DALYs 51.7 million. 95%UI 43.7-61.2), neural tube defects (DALYs 7.6 million. 95%UI 5.6-10.8), migraine (7.1 million, 95%UI 4.5-17.9) and idiopathic epilepsy (4.8 million, 95% UI 3.6-6.5); and communicable disorder meningitis (DALYs 12.5 million, 95%UI 10.2-15.6). Spanned from 1990 to 2019, the absolute number sharply decreased in DALYs (-42.9%) and deaths (-46.9%). Some DALYs could be attributed to risk factors lead exposure, low birth weight and short gestation, particular matter pollution, and alcohol use. Migraine rather than meningitis causes the second most DALYs in countries and territories with middle-, high-middle and high- sociodemographic index (SDI).