LncRNA GUSBP11/miR-28-5p/PAQR7 axis regulates the phosphorylation of E-cadherin and N-cadherin on the migration of papillary thyroid carcinoma cells

Papillary thyroid carcinoma represents the most prevalent form of thyroid cancer, exhibiting the lowest degree of malignancy. It constitutes approximately 85% of all thyroid cancer cases. This cancer type can manifest at any age but is predominantly observed in children or young women under the age of 40. The aberrant expression of long non-coding RNA (lncRNA) and messenger RNA (mRNA) has been identified as a crucial factor in the pathogenesis of this disease. Our analysis of existing databases revealed that lncRNA GUSBP11 and the membrane progesterone receptor PAQR7 are significantly overexpressed in thyroid cancer, demonstrating a notable positive correlation between them. However, RNA sequencing analysis indicated the absence of a direct relationship between these molecules. Through a comprehensive pooled analysis across multiple studies, we discovered a direct link between miR-28-5p and both lncRNA GUSBP11 and mRNA PAQR7, which were found to be significantly downregulated in thyroid cancer cases. This research endeavors to lay a novel foundation for the development of targeted therapy for thyroid cancer, focusing on the interaction between lncRNA, miRNA, and mRNA.