Assessment of Serum Survivin in Women with Placenta Previa and Accreta Spectrum: A Cross-sectional Study

Background This study aimed to assess maternal serum survivin levels in women with placenta previa, with and without placenta accreta spectrum (PAS), to understand its role in abnormal placental adherence and invasion. Methods In this prospective cross-sectional study, we enrolled 84 pregnant women categorized into control (n = 42), placenta previa (n = 24), and PAS (n = 28) groups. Serum survivin levels were quantitatively determined using ELISA, and statistical analyses were performed using ANOVA and post-hoc tests. Results A significant elevation in serum survivin levels was observed in the placenta previa and PAS groups compared to the controls (p < 0.05), suggesting that survivin plays a role in the pathophysiological response to abnormal placental adherence and invasion. Conclusions Elevated serum survivin levels may serve as an early biomarker for the diagnosis and management of placenta previa and PAS, aiding in the planning and timing of surgical interventions and the selection of appropriate surgical centers.