3-Month Prognostic Value of the Systemic Inflammatory Response Index Combined with Blood Glucose/ Potassium Ratio Score in Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

Objective In recent years, an increasing number of studies have focused on the use of readily available inflammatory markers to predict the prognosis of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). The systemic inflammatory response index combined with blood glucose/potassium ratio (SIRI-GPR) score is a new combination index that can reflect the inflammatory and stress status. However, whether this index can predict the prognosis of patients with AIS underwent IVT has not been reported. The purpose of our study was to investigate the role of the SIRI-GPR(systemic inflammatory response index combined with blood glucose/potassium ratio) score in predicting the prognosis of patients with AIS(acute ischemic stroke) who underwent IVT at 3 months. Methods We analyzed 247 patients with AIS admitted to the emergency department of the neurology department of the First Affiliated Hospital of Wenzhou Medical University from July 2021 to July 2022. The primary outcome was a 3-month prognosis. Univariate analysis and multivariate logistic regression were used to analyze the possible influencing factors of 3-month poor prognosis in patients with AIS after IVT. Independent factors were included in the construction of the clinical prediction model. We assessed the nomogram models using ROC and calibration curves. Results A total of 119 patients with AIS were finally included in the cohort study. Multifactorial logistic regression analysis showed no significant association between SIRI or GPR and 3-month functional prognosis, however, the SIRI-GPR score was found to be an independent predictor of 3-month dysfunction, In addition, it was also investigated whether large artery occlusion (OR = 5.836, 95% CI 1.123 ~ 30.337, P = 0.036) and NIHSS score within 24h after IVT (OR = 1.371, 95% CI 1.167 ~ 1.612, P < 0.001) were the independent influences of poor prognosis at 3 months (P < 0.05). The nomogram prediction model we constructed showed that the SIRI-GPR score was a good predictor of 3-month prognosis for these patients. Conclusion The SIRI-GPR score can predict the 3-month prognosis in stroke patients treated with IVT.