The association between neutrophil percentage and albumin ratio and early deterioration of neurological function after thrombolysis in acute ischemic stroke patients

Aim To investigate the correlation between neutrophil percentage to albumin ratio (NAPR) and early deterioration of neurological function after intravenous thrombolysis in acute ischemic stroke patients. Methods A retrospective analysis was conducted on 322 acute ischemic stroke patients who received intravenous thrombolysis at the Second Affiliated Hospital of Dalian Medical University from January 2021 to May 2024. 39 patients who experienced early neurological function deterioration (END) after ateplase thrombolysis, while the control group consisted of 283 patients whose symptoms improved after intravenous thrombolysis,we called early neurological improvement(ENI).Collect baseline data and blood parameters for statistical analysis. Results Compared with the control group, patients with higher initial NIHSS scores and NPAR had a higher incidence of early END after using thrombolysis (p = 0.041; P < 0.001). Conclusion NPAR is associated with early neurological deterioration after intravenous thrombolysis in acute ischemic stroke. Patients with higher NPAR are more prone to occur early neurological deterioration. NPAR is a cost-effective and useful biomarker for predicting early neurological deterioration in patients with acute ischemic stroke after intravenous thrombolysis.