Association between the monocyte-to-high-density lipoprotein cholesterol ratio and adult psoriasis: evidence from the NHANES

Background Psoriasis is a representative chronic inflammatory and hereditary disease. There was a significant association between the monocyte to high-density lipoprotein cholesterol (MHR) ratio and the psoriasis area and severity index (PASI) score. The correlation between MHR and psoriasis has not been well investigated. The authors sought to examine the correlation between the MHR and psoriasis in adult individuals living in the U.S. Methods This study used cross-sectional data from the NHANES conducted between 2009 and 2014. The data included information on persons aged 20 years or older in the U.S. Sample-weighted logistic regression and stratified subgroup analysis were employed. Results This study analyzed a total of 15,895 participants. There is a positive correlation between an increased MHR and a greater occurrence of psoriasis. When other confounding variables were controlled for, a significant correlation between the MHR and psoriasis was found (OR,1.364;95%CI，1.026-1.815). Based on subgroup analysis and interaction testing (p for interaction > 0.05), no statistically significant association was seen between sex, education level, diabetes, race, smoking status, coronary artery disease, age, congestive heart failure, and stroke. Conclusion The results revealed a positive association between the MHR and psoriasis. These findings suggest that the MHR could serve as a useful tool for identifying individuals who are more susceptible to developing psoriasis.