The relationship of retinal nerve fiber layer thickness and visual field parameter in eight sectors of primary open-angle glaucoma with high myopia based on spectral-domain OCT

To assess the structure-function relationship of retinal nerve fiber layer (RNFL) thickness in eight sectors based on spectral-domain optical coherence tomography (OCT) with visual field deviation in primary open-angle glaucoma(POAG) patients with high myopia. 225 eyes of 128 patients all diagnosed with POAG were enrolled and stratified by axial length(AL) into moderate ( 25mm ≤ AL < 25.99mm, n = 70 eyes), high (26mm ≤ AL < 26.99mm, n = 76 eyes) and super-high (27mm ≤ AL < 30mm, n = 79 eyes) myopia POAG groups. Data of RNFL thickness and visual field parameters was separated in eight sectors: superotemporal(ST), superonasal(SN), nasal-up(NU), nasal-low(NL), inferonasal(IN), inferotemporal(IT), temporal-low(TL), temporal-up(TU). The Pearson correlation coefficient analysis showed strong structure-function correlation in ST/IT (R = 0.654 to 0.741, p < 0.001) sectors despite AL elongation from 25mm to 30mm in myopia POAG. Also we found decreasing correlation in TL/TU/IN/SN (R = 0.264 to 0.595, p < 0.01) sectors with AL elongation in myopia POAG, with the changed node occurred in 27mm for IN/SN and in 26mm for TL/TU. Specially in NU/NL, the weak correlation(R = 0.233 to 0.381, p < 0.05) became no correlation(p > 0.05) when AL elongated from 25mm to 27mm and above. These descriptions may be helpful to observe and monitor the progression in POAG with high myopia.