X-ray Inactivation of SARS-CoV-2: A Safe, Cost-effective Approach for Pandemic Testing Workflows.
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In response to the unprecedented challenges posed by the COVID-19 pandemic, this study introduces a novel application of X-ray irradiation to rapidly inactivate SARS-CoV-2 variants, enabling safe and efficient virus handling outside high-containment facilities. Unlike traditional methods, X-ray irradiation preserves both the structural and genomic integrity of the virus, allowing for accurate detection through molecular and antigen-based diagnostics. Our findings not only demonstrate the method's superiority over gamma irradiation in terms of safety and cost but also its effectiveness in maintaining antigenic fidelity, critical for diagnostic reliability. Importantly, the scalability and accessibility of X-ray technology provide a transformative approach for managing future pandemic outbreaks, offering a robust tool for rapid viral inactivation that can significantly enhance global testing and research capabilities without the logistical and safety constraints of high-containment processing.
