Choroidal Blood Flow Changes in Central Serous Chorioretinopathy: Impact on Pigment Epithelial Detachment and Subretinal Fluid

Purpose Investigate how choroidal blood flow affacts pigment epithelial detachment (PED) and subretinal fluid (SRF) in central serous chorioretinopathy (CSC) . Methods We collected CSC patients, dividing into group with PED and without PED, as well as healthy individuals. Using SS-OCT to measure three-dimensional choroidal vascular index (CVI), choroidal vascular volume (CVV), SRF and PED area and volume, subfoveal choroidal thickness (SFCT), and the choroid thickness beneath the highest point of PED(PED-ct). Image-J was used to analyze and calculated flow void area (FVa) and flow void area percentage (FV%) of choriocapillary. Results The SFCT, three-dimensional CVI, CVV, FVa and FV% of CSC patients were higher than normal group, compared to CSC without PED, three-dimensional CVI in CSC with PED is higher, both difference was significant (P < 0.05). Among CSC patients, the FV% and SRF area, the CVV and SFCT all showed positive correlation. In CSC with PED, the CVV and PED-ct, the FVa, FV% and PED, SRF area were both positively correlated. Conclusions The occurrence of PED and SRF in CSC is not only related to the low blood flow of choriocapillary, but also related to the increase in the vascular density and the expansion of Sattler and Haller.