Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time

Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than the tumor, node, metastasis (TNM) stage, have been established. However, even within the same TNM stage, recurrence rates differ. Therefore, we developed a new prognostic confidence measure for gastric cancer recurrence and demonstrated its practical utility. In this retrospective study, we enrolled patients diagnosed with stage II/III gastric cancer who underwent complete surgical resection and adjuvant chemotherapy at the Chungnam National University Hospital, South Korea over the past 12 years. The associations among seven variables, including the systemic inflammation response index (SIRI), and gastric cancer recurrence was analyzed. A total of 296 patients were enrolled. Although other factors did not exhibit significance, the SIRI showed a positive correlation with gastric cancer recurrence risk, confirmed through Cox regression testing (hazard ratio, 1.231; 95% confidence interval, 1.04–1.45). Linear regression analysis revealed a significant association between higher SIRI values and shorter recurrence time (p = 0.044; β = −0.225). Other than the SIRI, effective prognostic factors related to gastric cancer recurrence were not verified. SIRI shows potential as an independent prognostic factor.