The implications of dynamic observation of immunoinflammatory indices in patients with resectable gastric cancer

Purpose Inflammatory immune markers and tumor markers are indicators obtained by laboratory tests and have also been shown to predict the prognosis of patients with gastric cancer, but most of the studies were analyzed by dichotomous classification or by taking cut-off values. In this study, we collected NLR, PLR, LMR, SII, PNI and CEA, AFP, CA125, CA199 from patients preoperatively, 3 months, 6 months, 9 months, and 12 months postoperatively, and analyzed the effect of their trends on the prognosis of patients with gastric cancer by latent category. Results A total of 93 gastric cancer patients were collected preoperative and postoperative data on inflammatory markers and tumor markers, and the trends of the data at multiple time points were analyzed by latent categories. On univariate analysis, only PNI trend (P < 0.013), surgical resection site (P < 0.034) and TNM stage (P < 0.017) were correlated with the prognosis of gastric cancer patients (P < 0.013). On multifactorial analysis, the trend change of PNI in different groups (P < 0.046) and TNM stage (P < 0.007) were independent risk factors for gastric cancer patients. Conclusion Evaluation of PNI at multiple time points has implications for the prognosis of patients with gastric cancer.