A retrospective Cohort Research of the Impact of Intraocular Lens (IOL) Loading Methods on the Adhesion Phenomenon during Cataract Surgery

Purpose This study aims to observe the optic and haptic adhesion phenomenon of different intraocular lens (IOL) and the impact of different methods of IOL loading on the occurrence of adhesion phenomena. Methods 253 patients (253 eyes) undergoing routine cataract surgery combined with IOL implantation at Peking University Third Hospital from July 2021 to July 2022 were enrolled. As an observative retrospective study, the Trial Registration Number (TRN) is not applicable for our research. Five types of IOLs including Tecnis ZCB00, Tecnis ZXR00, Tecnis ZMT, A1UV, and A1UL22 were selected and loaded using 7 different methods to compare the incidence of different IOL adhesion types and additional device assistance. Results The incidence of adhesion and additional device assistance in A1UV and A1UL22 groups were significantly higher than that in other three groups (P < 0.05). Routine loading method group exhibited the highest incidence of haptic adhesions (55%), while balanced salt solution (BSS) group presented the lowest incidence of haptic adhesions (5.9%, P < 0.05). BSS and viscoelastic group showed the highest incidence of double haptic loop adhesions (33%) among all the loading ways groups. Conclusions A1UV and its preloaded A1UL22 IOL presented the highest incidence of adhesion, compared with the other three IOLs (Tecnis ZCB00、Tecnis ZXR00、Tecnis ZMT). The application of BSS during IOL loading was effective in reducing the adhesion incidence.