Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations

The medial temporal lobe (MTL) is one of the key functional centers in the human brain, which participates in various higher-order cognitive functions, studies of brain connectivity in the MTL have received extensive attention. However, the brain network models have been used to be explored from the attributes of the whole-brain connectivity matrix. Brain local connectomes may be more valuable for analyzing the network mechanisms underlying brain functions and clinical neurological symptoms. Thus, in this study, we constructed the local structural connectomes for the MTL parcellations, included the amygdala, hippocampus, and parahippocampal gyrus, acquired the characteristics of the network topology parameters and the hubs distributions. Finally, we classified the major subtypes of these connectomes by hierarchical clustering, which demonstrated that the subtypes of these connectomes were closely related to the functions, providing a basis for further exploration of the functions and modifiable hubs within MTL parcellations.