Breast cancer therapy by both of laser and ultrasound irradiation with the aid of gold nanoparticles injection

Breast cancer is a disease in which cells in the breast grow out of control. After surgery, chemotherapy, and other invasive treatments, hyperthermia is a suitable choice with minimal side effects. This paper investigates the treatment of breast cancer using a combination of laser and ultrasound irradiation in the presence of gold nanoparticles. In the simulations, the breast tissue is represented as a multilayer structure, and the tumor is supposed to consist of two parts: a superficial section and a deeper region. In the initial stage, the superficial parts of the tumor, which also contain gold nanoparticles, are exposed to a continuous laser for 50 seconds, followed by a cooling period of 20 seconds. Then, for deeper sections, ultrasound irradiation is utilized. The results indicated that the application of nanoparticles enhanced the tissue necrosis volume. Furthermore, it was demonstrated that the combinational application of laser and ultrasound irradiation could eradicate both the superficial parts of the tumor and the deep parts.