Development and Characterization of Lansoprazole Nanosponges for Enhanced Solubility and Controlled Drug Release

This study presents the preparation and characterization of Lansoprazole nanosponges using soluble chitosan, polyvinyl alcohol (PVA), and Pluronic F68 via the emulsion solvent diffusion method. The nanosponges were formulated to enhance the drug's solubility and controlled release profile. Differential Scanning Calorimetry (DSC) confirmed the transition of Lansoprazole to an amorphous state, indicating uniform distribution within the nanosponge matrix. Scanning Electron Microscopy (SEM) revealed spherical, porous nanosponges. Dynamic Light Scattering (DLS) analysis showed an average particle size of 332.4 nm with a moderate polydispersity index (PDI) of 0.52, while zeta potential measurements indicated moderate stability with a value of -15.3 mV. Fourier-transform infrared (FTIR) spectroscopy confirmed the entrapment of Lansoprazole without significant interactions with the polymers. The in vitro drug release study demonstrated a controlled and sustained release profile, achieving nearly complete drug release over 11 hours. These findings suggest that the prepared Lansoprazole nanosponges possess the desired characteristics for potential therapeutic applications, offering improved solubility, stability, and a controlled release mechanism.